Current worldwide energy demand and consumption will increase from 524 quadrillion Btu in 2010 to 820 quadrillion in 2040, an increase of 56 percent. Chemical industries are the second largest users of energy in the manufacturing sector and the largest for delivered energy (19 percent of total global energy use in 2010). There is an urgent need for new, innovative, sustainable catalytic conversion processes to offset this global consumption within the industrial market. In the United States, the industrial sector is responsible for nearly a third of total energy use, where consumption is in energy-intensive processing. Breakthroughs are required so that bulk manufacturing of chemicals is performed at lower temperatures and catalytic conversion reactions are more selective and energy efficient. The Center for Integrated Mesoscale Architectures for Sustainable Catalysis (IMASC) is conducting transformative research in mesoscale science relevant to these issues.